A friend sent me a a blog post on happiness.
I distrust what any one person says about something as subjective as happiness. I would rather they show up with a slew of data from many people and say "let's try to make sense of this".
From what I know of neurochemistry, the drugs really matter. However, habituation to drug levels means that we need to cycle on/off drugs. Perhaps this is the root of needing downs to define the ups?